Pendrin-A New Target for Diuretic Therapy?
نویسنده
چکیده
منابع مشابه
A novel target for diuretic therapy.
The reabsorption of salt in the distal nephron is predominantly mediated via the thiazide-sensitive sodium chroride cotransporter, NCC (SLC12A3), and the chloride-bicarbonate exchanger pendrin (SLC26A4, PDS), with pendrin working in tandem with the epithelial sodium channel and NCC working by itself. Single deletion of NCC or pendrin in genetically engineered mouse models does not cause salt wa...
متن کاملSmall-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.
Pendrin is a Cl-/HCO3- exchanger expressed in type B and non-A, non-B intercalated cells in the distal nephron, where it facilitates Cl- absorption and is involved in Na+ absorption and acid-base balance. Pendrin-knockout mice show no fluid-electrolyte abnormalities under baseline conditions, although mice with double knockout of pendrin and the Na+/Cl- cotransporter (NCC) manifest profound sal...
متن کاملLife-threatening metabolic alkalosis in Pendred syndrome
INTRODUCTION Pendred syndrome, a combination of sensorineural deafness, impaired organification of iodide in the thyroid and goitre, results from biallelic defects in pendrin (encoded by SLC26A4), which transports chloride and iodide in the inner ear and thyroid respectively. Recently, pendrin has also been identified in the kidneys, where it is found in the apical plasma membrane of non-α-type...
متن کاملLow frequency of pendrin autoantibodies detected using a radioligand binding assay in patients with autoimmune thyroid disease.
CONTEXT Pendrin is a transmembrane protein located at the apical end of the thyrocyte in which it mediates the efflux of iodide through the thyroid follicular cell. Recently pendrin was described as a significant antibody target in Japanese patients with Graves' disease (GD) or autoimmune hypothyroidism (AH) using an immunoblotting assay. However, a subsequent study failed to verify this in aut...
متن کاملAmiloride vs hydrochlorthiazide therapy in children with nephrotic syndrome: A clinical trial
Background and Objective: To assess the effectiveness and safety of oral amiloride for the treatment of edema in pediatric patients with idiopathic nephrotic syndrome. Methods: A randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. The mean age was 4.3±0.7 years old. After a 2 week washout of diuretic therapy, nephrotic children with edema were randomized into two gr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of the American Society of Nephrology : JASN
دوره 27 12 شماره
صفحات -
تاریخ انتشار 2016